منابع مشابه
Nuclear importin α and its physiological importance
Importin α is recognized as a classical nuclear localization signal (cNLS) receptor which mediates nucleocytoplasmic transport. However, it rapidly accumulates in the nucleus in response to cellular stresses, including oxidative stress, causing a blockade of the classical nuclear import pathway. We set out to determine whether importin α performs roles in the nucleus after cellular exposure to ...
متن کاملAn Importin α Homolog, MOS6, Plays an Important Role in Plant Innate Immunity
Kristoffer Palma,1,2 Yuelin Zhang,1 and Xin Li1,3,* 1Michael Smith Laboratories Room 301, 2185 East Mall University of British Columbia Vancouver, British Columbia V6T 1Z4 Canada 2Genetics Graduate Program Room 308, 2206 East Mall University of British Columbia Vancouver, British Columbia V6T 1Z3 Canada 3Department of Botany Room 3529, 6270 University Boulevard University of British Columbia Va...
متن کاملAcetylation of importin-α nuclear import factors by CBP/p300
Histone acetylases were originally identified because of their ability to acetylate histone substrates [1–3]. Acetylases can also target other proteins such as transcription factors [4–7]. We asked whether the acetylase CREB-binding protein (CBP) could acetylate proteins not directly involved in transcription. A large panel of proteins, involved in a variety of cellular processes, were tested a...
متن کاملAn actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A
Myocardin-related transcription factors (MRTFs) are actin-regulated transcriptional coactivators, which bind G-actin through their N-terminal RPEL domains. In response to signal-induced actin polymerisation and concomitant G-actin depletion, MRTFs accumulate in the nucleus and activate target gene transcription through their partner protein SRF. Nuclear accumulation of MRTFs in response to sign...
متن کاملMutations in fission yeast Cut15, an importin α homolog, lead to mitotic progression without chromosome condensation
Chromosome condensation is a major mitotic event. Fission yeast mutations in topoisomerase II and condensin subunits produce the characteristic 'cut' phenotypes, in which the septum bisects the nuclear material in the absence of normal condensation and sister chromatid separation. We show here that the same condensation defect is produced in cut15 temperature-sensitive mutants at the restrictiv...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2011
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm3221